Investigating the epigenetic profile of the inflammatory gene IL-6 in late-life depression
作者: Joanne RyanLauren PilkingtonKatharina NeuhausKaren RitchieMarie-Laure AncelinRichard Saffery
作者单位: 1Monash University
2University of Melbourne
3INSERM, Univ Montpellier, Neuropsychiatry: Epidemiological and Clinical Research
刊名: BMC Psychiatry, 2017, Vol.17 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12888-017-1515-8
关键词: IL6DNA methylationEpigeneticsBuccalLate-life depressionAntidepressantsInflammation
英文摘要: It is well established that there is a link between inflammation and depression, with several studies reporting increased circulating levels of the pro-inflammatory cytokine, interleukin-6 ( IL6 ), in depressed individuals. Peripheral epigenetic marks, including DNA methylation, hold promise as biomarkers for a range of complex conditions, with potential to inform diagnosis and tailor interventions. The aim of this study was to determine whether individuals with depression display differential methylation of the IL6 gene promoter compared to individuals without depression.
原始语种摘要: It is well established that there is a link between inflammation and depression, with several studies reporting increased circulating levels of the pro-inflammatory cytokine, interleukin-6 ( IL6 ), in depressed individuals. Peripheral epigenetic marks, including DNA methylation, hold promise as biomarkers for a range of complex conditions, with potential to inform diagnosis and tailor interventions. The aim of this study was to determine whether individuals with depression display differential methylation of the IL6 gene promoter compared to individuals without depression.
全文获取路径: Springer Nature  (合作)
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影响因子:2.233 (2012)

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关键词翻译
关键词翻译
  • depression 低地
  • epigenetic 后成的
  • inflammatory 激怒的
  • promise 允诺
  • depressed 扁平的
  • methylation 甲基化酌
  • reporting 申报
  • inflammation 炎症
  • profile 纵断图
  • interleukin 白细胞间介素