Mesenchymal stromal cell-derived extracellular vesicles attenuate lung ischemia-reperfusion injury and enhance reconditioning of donor lungs after circulatory death
作者: Matthew L. StoneYunge ZhaoJ. Robert SmithMark L. WeissIrving L. KronVictor E. LaubachAshish K. Sharma
作者单位: 1University of Virginia
2Kansas State University
刊名: Respiratory Research, 2017, Vol.18 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12931-017-0704-9
关键词: Mesenchymal stromal cellsMicrovesiclesIschemia-reperfusion injuryEx vivo lung perfusionDonation after circulatory death
英文摘要: Lung ischemia-reperfusion (IR) injury after transplantation as well as acute shortage of suitable donor lungs are two critical issues impacting lung transplant patients. This study investigates the anti-inflammatory and immunomodulatory role of human mesenchymal stromal cells (MSCs) and MSC-derived extracellular vesicles (EVs) to attenuate lung IR injury and improve of ex-vivo lung perfusion (EVLP)-mediated rehabilitation in donation after circulatory death (DCD) lungs.
原始语种摘要: Lung ischemia-reperfusion (IR) injury after transplantation as well as acute shortage of suitable donor lungs are two critical issues impacting lung transplant patients. This study investigates the anti-inflammatory and immunomodulatory role of human mesenchymal stromal cells (MSCs) and MSC-derived extracellular vesicles (EVs) to attenuate lung IR injury and improve of ex-vivo lung perfusion (EVLP)-mediated rehabilitation in donation after circulatory death (DCD) lungs.
全文获取路径: Springer Nature  (合作)
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影响因子:3.642 (2012)

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关键词翻译
关键词翻译
  • reperfusion 多次灌注液
  • attenuate 衰减
  • circulatory 循环的
  • lungs 
  • reconditioning 重第
  • stromal 基质的
  • donor 给予体
  • extracellular 胞外的
  • injury 损害
  • death