In-vivo mapping of drusen by fundus autofluorescence and spectral-domain optical coherence tomography imaging
作者: Arno P. GöbelMonika FleckensteinTjebo F. C. HeerenFrank G. HolzSteffen Schmitz-Valckenberg
作者单位: 1University of Bonn
刊名: Graefe's Archive for Clinical and Experimental Ophthalmology, 2016, Vol.254 (1), pp.59-67
来源数据库: Springer Nature Journal
DOI: 10.1007/s00417-015-3012-4
关键词: Age-related macular degenerationDrusenGeographic atrophyFundus autofluorescenceScanning laser ophthalmoscopeSpectral-domain optical coherence tomography
英文摘要: Abstract(#br) Purpose(#br)To determine fundus autofluorescence (FAF) signal variations and corresponding microstructural alterations on spectral-domain optical coherence tomography (SD-OCT) in areas of funduscopically visible drusen associated with age-related macular degeneration (AMD).(#br) Methods(#br)Thirty eyes from 22 patients with geographic atrophy (GA) secondary to AMD (median age 74, range 64–87 years), who had undergone retinal imaging including color fundus photography (CFP), FAF and SD-OCT (Spectralis HRA+OCT; Heidelberg Engineering GmbH, Heidelberg, Germany) were retrospectively analyzed. In each eye, at least one druse (≥63 μm) in the perilesional zone of GA recorded on CFP was analyzed. Relative FAF intensities and alterations in SD-OCT bands at the site of each druse were...
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  • drusen 脉络膜小疣
  • fundus 
  • tomography 断层x 线摄影
  • imaging 图像形成
  • coherence 相干性
  • domain 领域
  • spectral 谱的
  • mapping 映象
  • optical 光学的