The roles and regulation of the actin cytoskeleton, intermediate filaments and microtubules in smooth muscle cell migration
作者: Dale D. TangBrennan D. Gerlach
作者单位: 1Albany Medical College
刊名: Respiratory Research, 2017, Vol.18 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12931-017-0544-7
关键词: Pulmonary Arterial HypertensionActin FilamentFocal Adhesion KinaseFocal AdhesionAirway Smooth Muscle
英文摘要: Smooth muscle cell migration has been implicated in the development of respiratory and cardiovascular systems; and airway/vascular remodeling. Cell migration is a polarized cellular process involving a protrusive cell front and a retracting trailing rear. There are three cytoskeletal systems in mammalian cells: the actin cytoskeleton, the intermediate filament network, and microtubules; all of which regulate all or part of the migrated process. The dynamic actin cytoskeleton spatially and temporally regulates protrusion, adhesions, contraction, and retraction from the cell front to the rear. c-Abl tyrosine kinase plays a critical role in regulating actin dynamics and migration of airway smooth muscle cells and nonmuscle cells. Recent studies suggest that intermediate filaments undergo...
原始语种摘要: Smooth muscle cell migration has been implicated in the development of respiratory and cardiovascular systems; and airway/vascular remodeling. Cell migration is a polarized cellular process involving a protrusive cell front and a retracting trailing rear. There are three cytoskeletal systems in mammalian cells: the actin cytoskeleton, the intermediate filament network, and microtubules; all of which regulate all or part of the migrated process. The dynamic actin cytoskeleton spatially and temporally regulates protrusion, adhesions, contraction, and retraction from the cell front to the rear. c-Abl tyrosine kinase plays a critical role in regulating actin dynamics and migration of airway smooth muscle cells and nonmuscle cells. Recent studies suggest that intermediate filaments undergo...
全文获取路径: Springer Nature  (合作)
分享到:
来源刊物:
影响因子:3.642 (2012)

×
关键词翻译
关键词翻译
  • migration 迁移
  • intermediate 中频
  • muscle 肌肉
  • actin 肌动蛋白
  • disassembly 分解
  • cells 麻风细胞
  • protrusive 构造侵入的
  • front 工祖
  • airway 航路
  • adhesion 粘附