Tanshinone I alleviates motor and cognitive impairments via suppressing oxidative stress in the neonatal rats after hypoxic-ischemic brain damage
作者: Chunfang DaiYannan LiuZhifang Dong
作者单位: 1Children’s Hospital of Chongqing Medical University
刊名: Molecular Brain, 2017, Vol.10 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s13041-017-0332-9
关键词: Hypoxic-ischemic brain damageTanshinone ILearning and memoryOxidative stress
英文摘要: Neonatal hypoxia-ischemia is one of the main reasons that cause neuronal damage and neonatal death. Several studies have shown that tanshinone I (TsI), one of the major ingredients of Danshen, exerts potential neuroprotective effect in adult mice exposed to permanent left cerebral ischemia. However, it is unclear whether administration of TsI has neuroprotective effect on neonatal hypoxic-ischemic brain damage (HIBD), and if so, the potential mechanisms also remain unclear. Here, we reported that treatment with TsI (5 mg/kg, i.p.) significantly alleviated the deficits of myodynamia and motor functions as well as the spatial learning and memory in the rat model of HIBD. These behavioral changes were accompanied by a significant decrease in the number of neuronal loss in the CA1 area of...
原始语种摘要: Neonatal hypoxia-ischemia is one of the main reasons that cause neuronal damage and neonatal death. Several studies have shown that tanshinone I (TsI), one of the major ingredients of Danshen, exerts potential neuroprotective effect in adult mice exposed to permanent left cerebral ischemia. However, it is unclear whether administration of TsI has neuroprotective effect on neonatal hypoxic-ischemic brain damage (HIBD), and if so, the potential mechanisms also remain unclear. Here, we reported that treatment with TsI (5 mg/kg, i.p.) significantly alleviated the deficits of myodynamia and motor functions as well as the spatial learning and memory in the rat model of HIBD. These behavioral changes were accompanied by a significant decrease in the number of neuronal loss in the CA1 area of...
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影响因子:4.202 (2012)

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关键词翻译
关键词翻译
  • neonatal 新生儿的
  • suppressing 制止的
  • hypoxic 含氧量低的
  • damage 损伤
  • ischemic 福尔克曼氏麻痹
  • brain 
  • oxidative 氧化的
  • potential 
  • stress 应力
  • superoxide 过氧化物