High wall shear stress and high-risk plaque: an emerging concept
作者: Parham EshtehardiAdam J. BrownAnkit BhargavaCharis CostopoulosOlivia Y. HungMichel T. CorbanHossein HosseiniBill D. GogasDon P. GiddensHabib Samady
作者单位: 1Emory University School of Medicine
2University of Cambridge
3Mayo Clinic School of Medicine
4Georgia Institute of Technology and Emory University
刊名: The International Journal of Cardiovascular Imaging, 2017, Vol.33 (7), pp.1089-1099
来源数据库: Springer Nature Journal
DOI: 10.1007/s10554-016-1055-1
关键词: Acute coronary syndromeCoronary artery diseaseComputational fluid dynamicsHigh-risk plaqueWall shear stress
英文摘要: In recent years, there has been a significant effort to identify high-risk plaques in vivo prior to acute events. While number of imaging modalities have been developed to identify morphologic characteristics of high-risk plaques, prospective natural-history observational studies suggest that vulnerability is not solely dependent on plaque morphology and likely involves additional contributing mechanisms. High wall shear stress (WSS) has recently been proposed as one possible causative factor, promoting the development of high-risk plaques. High WSS has been shown to induce specific changes in endothelial cell behavior, exacerbating inflammation and stimulating progression of the atherosclerotic lipid core. In line with experimental and autopsy studies, several human studies have shown...
原始语种摘要: In recent years, there has been a significant effort to identify high-risk plaques in vivo prior to acute events. While number of imaging modalities have been developed to identify morphologic characteristics of high-risk plaques, prospective natural-history observational studies suggest that vulnerability is not solely dependent on plaque morphology and likely involves additional contributing mechanisms. High wall shear stress (WSS) has recently been proposed as one possible causative factor, promoting the development of high-risk plaques. High WSS has been shown to induce specific changes in endothelial cell behavior, exacerbating inflammation and stimulating progression of the atherosclerotic lipid core. In line with experimental and autopsy studies, several human studies have shown...
全文获取路径: Springer Nature  (合作)
分享到:
来源刊物:

×
关键词翻译
关键词翻译
  • plaque 
  • stress 应力
  • events 定时
  • shear 切变
  • morphologic 形态学的
  • coronary 冠状的
  • stimulating 促进
  • recent 近来的
  • artery 动脉
  • interplay 互相作用