Low-shear-modeled microgravity-grown Penicillium chrysogenum -mediated biosynthesis of silver nanoparticles with enhanced antimicrobial activity and its anticancer effect in human liver cancer and fibroblast cells
作者: Sunirmal SheetYesupatham SathishkumarAllur Subramaniyam SivakumarKwan Seob ShimYang Soo Lee
作者单位: 1College of Agriculture and Life Sciences, Chonbuk National University
2Korea Advanced Institute of Science and Technology
刊名: Bioprocess and Biosystems Engineering, 2017, Vol.40 (10), pp.1529-1542
来源数据库: Springer Nature Journal
DOI: 10.1007/s00449-017-1809-8
关键词: Silver nanoparticlesLow-shear-modeled microgravityHARVIn vitro cytotoxicityBactericidal activity
原始语种摘要: Gravitational force and shear forces induce various changes in gene expression and metabolite production of microorganisms. Previous reports have shown that there are differences in the expression of different sets of proteins and enzymes under microgravity conditions compared to normal gravity. The aim of this study is to utilize culture filtrates of Penicillium chrysogenum grown under microgravity and normal conditions to synthesize silver nanoparticles and to examine whether there is any difference between their physiochemical and biological function. Synthesized nanoparticles were characterized using UV–Vis spectroscopy, FTIR, XRD, and TEM. Biological functional studies such as antimicrobial activity, cytotoxic studies, and anticancer activity were carried out. Antimicrobial activity...
全文获取路径: Springer Nature  (合作)
影响因子:1.869 (2012)

  • silver 
  • microgravity 微重力
  • nanoparticle 乳酸
  • activity 活度
  • grown 生长
  • antimicrobial 杀菌剂
  • anticancer 抗癌的
  • cytotoxic 细胞毒素的
  • enhanced 增强
  • physiochemical 生物化学的