Lipid overload during gestation and lactation can independently alter lipid homeostasis in offspring and promote metabolic impairment after new challenge to high-fat diet
作者: Laís Angélica de Paula SiminoThaís de FanteMarina Figueiredo FontanaFernanda Oliveira BorgesMárcio Alberto TorsoniMarciane MilanskiLício Augusto VellosoAdriana Souza Torsoni
作者单位: 1University of Campinas -UNICAMP
2University Of Campinas - UNICAMP
刊名: Nutrition & Metabolism, 2017, Vol.14 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12986-017-0168-4
关键词: MicroRNAsMaternal obesityMetabolic programmingNAFLD
英文摘要: Nutritional status in early life is critically involved in the metabolic phenotype of offspring. However the changes triggered by maternal consumption of high-fat diet (HFD) in pre- or postnatal period should be better understood. Here we evaluated whether maternal HFD consumption during gestation and lactation could differently affect liver miR-122 and miR-370 expression leading to metabolic damages observed in offspring. Moreover, we investigate whether early overnutrition program offspring to more harmful response to HFD in later life.
原始语种摘要: Nutritional status in early life is critically involved in the metabolic phenotype of offspring. However the changes triggered by maternal consumption of high-fat diet (HFD) in pre- or postnatal period should be better understood. Here we evaluated whether maternal HFD consumption during gestation and lactation could differently affect liver miR-122 and miR-370 expression leading to metabolic damages observed in offspring. Moreover, we investigate whether early overnutrition program offspring to more harmful response to HFD in later life.
全文获取路径: Springer Nature  (合作)
分享到:
来源刊物:
影响因子:3.156 (2012)

×
关键词翻译
关键词翻译
  • offspring 后代
  • lactation 哺乳
  • gestation 妊娠
  • triggered 触发的
  • observed 观察到的
  • investigate 
  • expression 表示
  • overnutrition 过营养
  • consumption 消耗
  • programming 程序设计