Identification of placental genes linked to selective intrauterine growth restriction (IUGR) in dichorionic twin pregnancies: gene expression profiling study
作者: Lidia BiesiadaAgata SakowiczMariusz GrzesiakMaciej BorowiecMichalina LisowskaTadeusz PietruchaConstantin KaisenbergKrzysztof Lewandowski
作者单位: 1Department of Obstetrics, Perinatology and Gynecology, Polish Mother’s Memorial Hospital-Research Institute in Lodz
2Department of Medical Biotechnology, Medical University of Lodz
3Department of Clinical Genetic, Medical University of Lodz
4Department of Obstetrics and Gynecology, Hannover Medical School
5Department of Endocrinology and Metabolic Diseases, Polish Mother’s Memorial Hospital-Research Institute in Lodz
刊名: Human Genetics, 2019, Vol.138 (6), pp.649-659
来源数据库: Springer Nature Journal
DOI: 10.1007/s00439-019-02016-6
英文摘要: Abstract(#br)A linkage of dichorionic (DC) twin pregnancies with selective intrauterine growth restriction (IUGR) to alterations in placental gene expression is unclear. The aim of the study was to identify placental genes related to hypoxia, adipogenesis and human growth which may contribute to IUGR development. The study group (IUGR/AGA) comprised dichorionic (DC) twin pregnancies, where the weight of the twins differed by > 15%; in addition, one twin was small for gestational age (< 10th percentile-SGA) (IUGR) while the other was appropriate for gestational age (> 10th percentile-AGA). In the control group (AGA/AGA), both fetuses were AGA and their weights differed by < 15%. In the first step (selection), placental expression of 260 genes was analysed by commercial PCR profiler array...
全文获取路径: Springer Nature  (合作)
影响因子:4.633 (2012)