Genome-wide association study of coronary artery calcified atherosclerotic plaque in African Americans with type 2 diabetes
作者: Jasmin DiversNicholette D. PalmerCarl D. LangefeldW. Mark BrownLingyi LuPamela J. HicksS. Carrie SmithJianzhao XuJames G. TerryThomas C. RegisterLynne E. WagenknechtJohn S. ParksLijun MaGary C. ChanSarah G. BuxbaumAdolfo CorreaSolomon MusaniJames G. WilsonHerman A. TaylorDonald W. BowdenJohn Jeffrey CarrBarry I. Freedman
作者单位: 1Medical Center Boulevard
2Wake Forest School of Medicine
3Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine
4Vanderbilt University School of Medicine
5Department of Pathology, Wake Forest School of Medicine
6Department of Epidemiology, Wake Forest School of Medicine
7Department of Internal Medicine–Section on Molecular Medicine, Wake Forest School of Medicine
8School of Public Health Initiative, Jackson State University
9Department of Medicine
10University of Mississippi Medical Center
11Morehouse School of Medicine, Morehouse College
12Vanderbilt Univer
刊名: BMC Genetics, 2017, Vol.18 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12863-017-0572-9
关键词: African AmericansCoronary artery calcified atherosclerotic plaqueGenome-wide association studyCardiovascular diseaseType 2 diabetesGenetics
原始语种摘要: Coronary artery calcified atherosclerotic plaque (CAC) predicts cardiovascular disease (CVD). Despite exposure to more severe conventional CVD risk factors, African Americans (AAs) are less likely to develop CAC, and when they do, have markedly lower levels than European Americans. Genetic factors likely contribute to the observed ethnic differences. To identify genes associated with CAC in AAs with type 2 diabetes (T2D), a genome-wide association study (GWAS) was performed using the Illumina 5 M chip in 691 African American-Diabetes Heart Study participants (AA-DHS), with replication in 205 Jackson Heart Study (JHS) participants with T2D. Genetic association tests were performed on the genotyped and 1000 Genomes-imputed markers separately for each study, and combined in a meta-analysis.
全文获取路径: Springer Nature  (合作)
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影响因子:2.808 (2012)

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关键词翻译
关键词翻译
  • plaque 
  • diabetes 糖尿病
  • association 联合
  • artery 动脉
  • coronary 冠状的
  • African 非洲的
  • associated 相关的
  • combined 组合
  • markers 时标
  • likely 大概