Overexpression of the CHRNA5/A3/B4 genomic cluster in mice increases the sensitivity to nicotine and modifies its reinforcing effects
作者: Xavier GallegoSusanna MolasAlejandro Amador-ArjonaMichael J. MarksNoemí RoblesPatricia MurtraLluís ArmengolRubén D. Fernández-MontesMònica GratacòsMartí PumarolaRoberto CabreraRafael MaldonadoJosefa SabriàXavier EstivillMara Dierssen
作者单位: 1Genes and Disease Program, Center for Genomic Regulation (CRG)
2CIBER de Enfermedades Raras (CIBERER), CRG and UPF
3Department of Biochemistry, Autonomous University of Barcelona (UAB)
4Unit of Neuropharmacology, Pompeu Fabra University (UPF)
5Institute of Neuroscience, Miguel Hernández University, Consejo Superior de Investigaciones Científicas (CSIC)
6Department of Animal Medicine and Surgery, Autonomous University of Barcelona (UAB)
7Unit of Genetics, Pompeu Fabra University (UPF)
8Institute for Behavioral Genetics, University of Colorado at Boulder
刊名: Amino Acids, 2012, Vol.43 (2), pp.897-909
来源数据库: Springer Nature Journal
DOI: 10.1007/s00726-011-1149-y
关键词: α5α3β4 Nicotinic receptor subunitsCHRNA5/A3/B4 genomic clusterVTAMHbNicotine addiction
英文摘要: Abstract(#br)Nicotinic acetylcholine receptors (nAChRs) are ligand-gated pentameric ion channels that account for the effects of nicotine. Recent genetic studies have highlighted the importance of variants of the CHRNA5/A3/B4 genomic cluster in human nicotine dependence. Among these genetic variants those found in non-coding segments of the cluster may contribute to the pathophysiology of tobacco use through alterations in the expression of these genes. To discern the in vivo effects of the cluster, we generated a transgenic mouse overexpressing the human CHRNA5/A3/B4 cluster using a bacterial artificial chromosome. Transgenic mice showed increased functional α3β4-nAChRs in brain regions where these subunits are highly expressed under normal physiological conditions. Moreover, they...
全文获取路径: Springer Nature  (合作)
影响因子:3.914 (2012)

  • reinforcing 配筋
  • cluster 
  • nicotine 尼古丁
  • sensitivity 灵敏度
  • genomic 染色体组的
  • effects 海员自身物品