Common olfactory ensheathing glial markers in the developing human olfactory system
作者: Karen OprychDaniel CotfasDavid Choi
作者单位: 1University College London
2National Hospital for Neurology and Neurosurgery
刊名: Brain Structure and Function, 2017, Vol.222 (4), pp.1877-1895
来源数据库: Springer Nature Journal
DOI: 10.1007/s00429-016-1313-y
关键词: OECOlfactory ensheathing cellsHumanOlfactory bulbFoetalImmunocytochemistry
英文摘要: The in situ immunocytochemical properties of olfactory ensheathing cells (OECs) have been well studied in several small to medium sized animal models including rats, mice, guinea pigs, cats and canines. However, we know very little about the antigenic characteristics of OECs in situ within the adult and developing human olfactory bulb and nerve roots. To address this gap in knowledge we undertook an immunocytochemical analysis of the 11–19 pcw human foetal olfactory system. Human foetal OECs in situ possessed important differences compared to rodents in the expression of key surface markers. P75NTR was not observed in OECs but was strongly expressed by human foetal Schwann cells and perineurial olfactory nerve fibroblasts surrounding OECs. We define OECs throughout the 11–19...
原始语种摘要: The in situ immunocytochemical properties of olfactory ensheathing cells (OECs) have been well studied in several small to medium sized animal models including rats, mice, guinea pigs, cats and canines. However, we know very little about the antigenic characteristics of OECs in situ within the adult and developing human olfactory bulb and nerve roots. To address this gap in knowledge we undertook an immunocytochemical analysis of the 11–19 pcw human foetal olfactory system. Human foetal OECs in situ possessed important differences compared to rodents in the expression of key surface markers. P75NTR was not observed in OECs but was strongly expressed by human foetal Schwann cells and perineurial olfactory nerve fibroblasts surrounding OECs. We define OECs throughout the 11–19...
全文获取路径: Springer Nature  (合作)
分享到:
来源刊物:
影响因子:7.837 (2012)

×
关键词翻译
关键词翻译
  • olfactory 嗅觉的
  • developing 显影
  • human 人的
  • markers 时标
  • glial 神经胶质的
  • cells 麻风细胞
  • nerve 叶脉
  • expression 表示
  • animal 动物的
  • OEC Orientation Execution Code