Low expression of dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin in non-Hodgkin lymphoma and a significant correlation with β2-microglobulin
作者: Dongbing DingWenbin ChenChangfu ZhangZhe ChenYanmei JiangZiyi YangXudong JiangYunfei ZuoShuangyi Ren
作者单位: 1Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University
2Department of Clinical Biochemistry, College of Laboratory Diagnostic Medicine, Dalian Medical University
3Department of Clinical Laboratory, The First Affiliated Hospital of Dalian Medical University
刊名: Medical Oncology, 2014, Vol.31 (10), pp.1-10
来源数据库: Springer Nature Journal
DOI: 10.1007/s12032-014-0202-6
关键词: DC-SIGNNon-Hodgkin lymphomaCorrelationβ2-Microglobulin
英文摘要: Abstract(#br)Dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), a member of the C-type lectin superfamily, has been reported to bind to various pathogens and several tumor cells and to participate in immunoregulation. It is still unclear whether there is a significant association between the level of DC-SIGN and non-Hodgkin lymphoma (NHL). To investigate the clinical diagnostic significance of DC-SIGN in NHL, we conducted a study with 52 NHL patients and 104 healthy individuals. Enzyme-linked immunosorbent assay and tissue microarray technology were utilized for the analysis. The serum sDC-SIGN levels in the NHL patients were significantly lower than those in the healthy controls ( P = 0.0019). A cutoff value of 1.499 µg/ml for sDC-SIGN predicted the...
全文获取路径: Springer Nature  (合作)
影响因子:2.147 (2012)

  • microglobulin 小球蛋白
  • grabbing 抡夺
  • dendritic 师状的
  • adhesion 粘附
  • lymphoma 淋巴瘤
  • molecule 分子
  • intercellular 细胞间的
  • expression 表示
  • correlation 对比
  • specific