Characterization of IgG glycosylation in rheumatoid arthritis patients by MALDI-TOF-MS n and capillary electrophoresis
作者: Chuncui HuangYaming LiuHongmei WuDehui SunYan Li
作者单位: 1Chinese Academy of Sciences
2GuangDong Bio-Healtech Advanced Co., Ltd
3University of Chinese Academy of Sciences
刊名: Analytical and Bioanalytical Chemistry, 2017, Vol.409 (15), pp.3731-3739
来源数据库: Springer Nature Journal
DOI: 10.1007/s00216-017-0302-1
关键词: CharacterizationGlycosylationRheumatoid arthritisMALDI-TOF-MSnCapillary electrophoresis
英文摘要: An analytical method based on the combination of multistage mass spectrometry (MSn) and capillary electrophoresis (CE) was developed for the analysis of immunoglobulin G (IgG) glycosylation in rheumatoid arthritis (RA) patients. It has been recently suggested that IgG glycosylation defect may be involved in RA immunopathogenesis. Complete characterization of glycans, including both qualitative and quantitative analysis, requires a combination of different techniques, and accurate, robust, sensitive, and high-throughput methodologies are important for analysis of clinical samples. In the present study, N- glycosylation of IgG in RA patients and in healthy people was characterized through identification of the released glycans using multistage matrix-assisted laser...
原始语种摘要: An analytical method based on the combination of multistage mass spectrometry (MSn) and capillary electrophoresis (CE) was developed for the analysis of immunoglobulin G (IgG) glycosylation in rheumatoid arthritis (RA) patients. It has been recently suggested that IgG glycosylation defect may be involved in RA immunopathogenesis. Complete characterization of glycans, including both qualitative and quantitative analysis, requires a combination of different techniques, and accurate, robust, sensitive, and high-throughput methodologies are important for analysis of clinical samples. In the present study, N- glycosylation of IgG in RA patients and in healthy people was characterized through identification of the released glycans using multistage matrix-assisted laser...
全文获取路径: Springer Nature  (合作)
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来源刊物:
影响因子:3.659 (2012)

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关键词翻译
关键词翻译
  • glycosylation 糖基化
  • arthritis 关节炎
  • rheumatoid 患风湿病的
  • IgG 免疫球蛋白 G
  • capillary 毛状的
  • TOF Time Of Filling
  • analysis 分析
  • immunoglobulin 免疫球蛋白
  • flight 飞行
  • throughput 吞吐量