Effects of retinoic acid and zinc on the treatment of caustic esophageal burns
作者: Nergul CordukUgur KoltuksuzNese Callı-DemirkanSimin RotaGulcin AbbanAkile Sarioglu-Buke
作者单位: 1Pamukkale University
刊名: Pediatric Surgery International, 2010, Vol.26 (6), pp.619-624
来源数据库: Springer Nature Journal
DOI: 10.1007/s00383-010-2571-z
关键词: Esophageal burnFibrosisInflammationZincRetinoic acidTGF-β1
英文摘要: Abstract(#br) Purpose(#br)An experimental study was carried out to investigate the efficacy of an anti-inflammatory and antiproliferative agent all- trans retinoic acid (ATRA) and an antioxidant agent zinc sulphate (ZnSO 4 ) in the prevention of stricture after caustic esophageal burn in rats.(#br) Methods(#br)Esophageal burn was induced using 50% NaOH. Rats were divided into four groups as follows: group A (sham; n = 8), group B (control; n = 8), group C (treated with ATRA; n = 8) and group D (treated with ZnSO 4 ; n = 8). All rats were killed on the 28th day and esophageal tissues were evaluated for histopathologic damage score, hydroxyproline (HP) content and TGF-β1 expression.(#br) Results(#br)Significant difference was detected in terms of histopathologic damage score between groups...
全文获取路径: Springer Nature  (合作)
影响因子:1.216 (2012)

  • caustic 焦散线
  • esophageal 食管的
  • burns 烧伤
  • treatment 处理