Exploring the binding of two potent anticancer drugs bosutinib and imatinib mesylate with bovine serum albumin: spectroscopic and molecular dynamic simulation studies
作者: Suma K. PawarRoopa S. NaikJ. Seetharamappa
作者单位: 1Karnatak University
刊名: Analytical and Bioanalytical Chemistry, 2017, Vol.409 (27), pp.6325-6335
来源数据库: Springer Nature Journal
DOI: 10.1007/s00216-017-0565-6
关键词: InteractionBosutinibImatinib mesylateΒ-CyclodextrinMolecular dynamic simulation
英文摘要: Bosutinib (BST) and imatinib mesylate (IMT) are tyrosine kinase inhibitors (TKIs). In view of the importance of these inhibitors in cancer treatment, we investigated the mechanism of interaction between BST/IMT and bovine serum albumin (BSA) using various spectroscopic and molecular docking methods. Fluorescence studies indicated that BST/IMT interacted with BSA without affecting the microenvironment around the residue Trp213 of BSA. The quenching mechanism associated with the BST–BSA and IMT–BSA interactions was determined by performing fluorescence measurements at different temperatures. These results suggested that BST and IMT quenched the fluorescence intensity of BSA through static and dynamic processes, respectively, which was confirmed by time-resolved fluorescence measurements....
原始语种摘要: Bosutinib (BST) and imatinib mesylate (IMT) are tyrosine kinase inhibitors (TKIs). In view of the importance of these inhibitors in cancer treatment, we investigated the mechanism of interaction between BST/IMT and bovine serum albumin (BSA) using various spectroscopic and molecular docking methods. Fluorescence studies indicated that BST/IMT interacted with BSA without affecting the microenvironment around the residue Trp213 of BSA. The quenching mechanism associated with the BST–BSA and IMT–BSA interactions was determined by performing fluorescence measurements at different temperatures. These results suggested that BST and IMT quenched the fluorescence intensity of BSA through static and dynamic processes, respectively, which was confirmed by time-resolved fluorescence measurements....
全文获取路径: Springer Nature  (合作)
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影响因子:3.659 (2012)

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关键词翻译
关键词翻译
  • mesylate 甲磺酸盐
  • spectroscopic 光谱的
  • potent 强大的
  • anticancer 抗癌的
  • dynamic 动力学的
  • binding 装订
  • serum 血清
  • simulation 模拟
  • molecular 分子的
  • BST BurST WAIT