Regular aspirin use and gene expression profiles in prostate cancer patients
作者: Konrad H. StopsackEricka M. EbotMary K. DownerTravis A. GerkeJennifer R. RiderPhilip W. KantoffLorelei A. Mucci
作者单位: 1Department of Internal Medicine, Mayo Clinic
2Department of Epidemiology, Harvard T.H. Chan School of Public Health
3Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
4Department of Cancer Epidemiology, Moffitt Cancer Center
5Department of Epidemiology, Boston University School of Public Health
6Department of Medicine, Memorial Sloan Kettering Cancer Center
刊名: Cancer Causes & Control, 2018, Vol.29 (8), pp.775-784
来源数据库: Springer Nature Journal
DOI: 10.1007/s10552-018-1049-5
关键词: AspirinTranscriptomeRibosomePrognosisProstate cancer
英文摘要: Abstract(#br) Purpose(#br)Pharmacoepidemiology studies suggest prognostic benefits of aspirin in prostate cancer. We hypothesized that aspirin induces transcriptional changes in tumors or normal prostate tissue.(#br) Methods(#br)We analyzed the prostatic transcriptome from men diagnosed with prostate cancer during follow-up of the Physicians’ Health Study 1 (PHS, n = 149), initially a randomized controlled trial of aspirin. Aspirin target genes were identified through systematic literature review and a drug target database. We compared target gene expression according to regular aspirin use at cancer diagnosis and used whole-transcriptome gene set enrichment analysis to identify gene sets associated with aspirin use. Results were validated in the Health Professionals Follow-up Study...
全文获取路径: Springer Nature  (合作)
影响因子:3.2 (2012)