Klf8 regulates left-right asymmetric patterning through modulation of Kupffer’s vesicle morphogenesis and spaw expression
作者: Che-Yi LinMing-Yuan TsaiYu-Hsiu LiuYu-Fen LuYi-Chung ChenYun-Ren LaiHsin-Chi LiaoHuang-Wei LienChung-Hsiang YangChang-Jen HuangSheng-Ping L. Hwang
作者单位: 1National Taiwan Ocean University
2Present address: Institute of Cellular and Organismic Biology, Academia Sinica
3Graduate Institute of Life Sciences, National Defence Medical Center, National Defence University
4National Taiwan University
5Institute of Cellular and Organismic Biology, Academia Sinica
6Institute of Biological Chemistry, Academia Sinica
刊名: Journal of Biomedical Science, 2017, Vol.24 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12929-017-0351-y
关键词: ZebrafishKlf8SpawL-R patterningKupffer’s vesicle
原始语种摘要: Although vertebrates are bilaterally symmetric organisms, their internal organs are distributed asymmetrically along a left-right axis. Disruption of left-right axis asymmetric patterning often occurs in human genetic disorders. In zebrafish embryos, Kupffer’s vesicle, like the mouse node, breaks symmetry by inducing asymmetric expression of the Nodal -related gene, spaw , in the left lateral plate mesoderm (LPM). Spaw then stimulates transcription of itself and downstream genes, including lft1 , lft2 , and pitx2 , specifically in the left side of the diencephalon, heart and LPM. This developmental step is essential to establish subsequent asymmetric organ positioning. In this study, we evaluated the role of krüppel-like factor 8 ( klf8 ) in regulating left-right asymmetric patterning in...
全文获取路径: Springer Nature  (合作)
影响因子:2.458 (2012)

  • asymmetric 不对称的
  • expression 表示
  • patterning 图案形成
  • right 右边的
  • vesicle 气泡
  • organs 男生殖器
  • mesoderm 中胚层
  • diencephalon 间脑
  • genetic 遗传的
  • bilaterally 双向地