Dose-dependent effects of intravenous methoxamine infusion during hip-joint replacement surgery on postoperative cognitive dysfunction and blood TNF-α level in elderly patients: a randomized controlled trial
作者: Shenghui SunDefeng SunLin YangJun HanRuochuan LiuLijie Wang
作者单位: 1Affiliated High School of Liaoning Normal University
2The First Affiliated Hospital of Dalian Medical University
刊名: BMC Anesthesiology, 2017, Vol.17 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12871-017-0367-6
关键词: MethoxamineElderly patientsHip-joint replacement surgeryPostoperative cognitive dysfunctionTumor necrosis factor-α
原始语种摘要: Postoperative cognitive dysfunction (POCD), common in elderly patients, is thought to be closely associated with intraoperative instability of hemodynamics and excessive excretion of tumor necrosis factor-α (TNF-α). Methoxamine is a blood-pressure increasing drug commonly used for maintaining intraoperative hemodynamics. Methoxamine potentially promotes TNF-α expression, leading to an increased risk of POCD. This study aimed to investigate the dose-dependent effect of methoxamine on the incidence of early POCD and blood TNF-α level.
全文获取路径: Springer Nature  (合作)
影响因子:1.188 (2012)

  • methoxamine 甲氧明
  • replacement 交代
  • elderly 上了年纪的
  • postoperative 手术后的
  • joint 节理
  • controlled 受控
  • dysfunction 功能障碍
  • infusion 浸剂
  • intravenous 静脉内的
  • hemodynamics 血力学