DHA increases adiponectin expression more effectively than EPA at relative low concentrations by regulating PPARγ and its phosphorylation at Ser273 in 3T3-L1 adipocytes
作者: Jia SongCheng LiYushan LvYi ZhangWilliam Kwame AmakyeLimei Mao
作者单位: 1Southern Medical University
刊名: Nutrition & Metabolism, 2017, Vol.14 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12986-017-0209-z
关键词: AdiponectinDHAEPAPPARγPPARγ phosphorylation
英文摘要: Enhancing circulating adiponectin is considered as a potential approach for the prevention and treatment of non-communicable diseases (NCDs). Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) were reported to increase adiponectin by previous studies using a mixture of them. However, their individual effects on adiponectin and the underlying mechanisms are still unclear. In the present study, we observed and compared the individual effect of DHA and EPA on adiponectin in 3T3-L1 adipocytes, and further tested whether DHA or EPA regulated adiponectin by peroxisome proliferator-activated receptor γ (PPARγ) and its phosphorylation at Ser273 to provide a plausible explanation for their distinct actions.
原始语种摘要: Enhancing circulating adiponectin is considered as a potential approach for the prevention and treatment of non-communicable diseases (NCDs). Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) were reported to increase adiponectin by previous studies using a mixture of them. However, their individual effects on adiponectin and the underlying mechanisms are still unclear. In the present study, we observed and compared the individual effect of DHA and EPA on adiponectin in 3T3-L1 adipocytes, and further tested whether DHA or EPA regulated adiponectin by peroxisome proliferator-activated receptor γ (PPARγ) and its phosphorylation at Ser273 to provide a plausible explanation for their distinct actions.
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影响因子:3.156 (2012)

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关键词翻译
关键词翻译
  • relative 相对的
  • expression 表示
  • EPA Entry Point Address
  • more 更多
  • distinct 相异的
  • observed 观察到的
  • effectively 有效地
  • communicable 有传染性的
  • DHA 达兰
  • further 进一步