Involvement of mitochondrial pathway in environmental metal pollutant lead-induced apoptosis of chicken liver: perspectives from oxidative stress and energy metabolism
作者: Qianru ChiTianqi LiuZhepeng SunSiran TanShiping LiShu Li
作者单位: 1Northeast Agricultural University
刊名: Environmental Science and Pollution Research, 2017, Vol.24 (36), pp.28121-28131
来源数据库: Springer Nature Journal
DOI: 10.1007/s11356-017-0411-6
关键词: LeadChicken liverMitochondrial pathwayOxidative stressEnergy metabolism disorderApoptosis
英文摘要: This study aimed to investigate the possible mechanisms of environmental metal pollutant lead (Pb)-induced apoptosis in chicken. Forty 8-day-old healthy chickens were randomly assigned to two groups ( n = 20/group) after raising standard commercial diet and drinking water for 1 week: including control group and Pb group ((CH3COO)2Pb 350 mg/L of drinking water); the chickens were given euthanasia and collected livers at 90 days. A significant increase of apoptosis rate were found in Pb group and Pb induced obvious ultrastructural changes of chicken liver. The mRNA levels of glycometabolism key enzymes were significantly lower in Pb group than those in controls. Higher levels of malondialdehyde (MDA) and nitric oxide (NO) were observed in Pb group; the activities of...
原始语种摘要: This study aimed to investigate the possible mechanisms of environmental metal pollutant lead (Pb)-induced apoptosis in chicken. Forty 8-day-old healthy chickens were randomly assigned to two groups ( n = 20/group) after raising standard commercial diet and drinking water for 1 week: including control group and Pb group ((CH3COO)2Pb 350 mg/L of drinking water); the chickens were given euthanasia and collected livers at 90 days. A significant increase of apoptosis rate were found in Pb group and Pb induced obvious ultrastructural changes of chicken liver. The mRNA levels of glycometabolism key enzymes were significantly lower in Pb group than those in controls. Higher levels of malondialdehyde (MDA) and nitric oxide (NO) were observed in Pb group; the activities of...
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影响因子:2.618 (2012)

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关键词翻译
关键词翻译
  • induced 感应的
  • liver 
  • pathway 轨道
  • mitochondrial 线粒体的
  • metabolism 代谢
  • chicken 小鸡
  • stress 应力
  • apoptosis 细胞死
  • pollutant 污染物质
  • controls 控制机构