Autophagy response in the liver of pigeon exposed to avermectin
作者: Xian-Song WangCi LiuPervez Ahmed KhosoWeijia ZhengMing LiShu Li
作者单位: 1Northeast Agricultural University
2Daqing Normal College
刊名: Environmental Science and Pollution Research, 2017, Vol.24 (14), pp.12767-12777
来源数据库: Springer Nature Journal
DOI: 10.1007/s11356-016-6209-0
关键词: AvermectinPigeonLiver tissueAutophagyPesticideResidue
原始语种摘要: Pesticide residues are an important aspect of environmental pollution. Environmental avermectin residues have produced adverse effects in organisms. Many pesticides exert their toxic effects via the mechanism of autophagy. The purpose of this study was to examine the changes in autophagy levels and in autophagy-related genes, including LC3, Beclin 1, Dynein, ATG5, TORC1, and TORC2, resulting from exposure to subchronic levels of AVM in liver tissue in the king pigeon model. We observed abundant autophagic vacuoles with extensively degraded organelles, autophagosomal vacuoles, secondary lysosomes, and double-membrane structures in the liver. The expression levels of the autophagy-related genes LC3-I, LC3-II, Beclin 1, ATG5, and Dynein were up-regulated; however, TORC1 and TORC2 expression...
全文获取路径: Springer Nature  (合作)
影响因子:2.618 (2012)

  • avermectin 除虫菌素
  • liver 
  • pigeon 
  • expression 表示
  • abundant 丰富的
  • related 有关的
  • autophagy 自体消瘦
  • together 共同
  • observed 观察到的
  • examine