A spleen tyrosine kinase inhibitor attenuates the proliferation and migration of vascular smooth muscle cells
作者: Hyang-Hee SeoSang Woo KimChang Youn LeeKyu Hee LimJiyun LeeEunhyun ChoiSoyeon LimSeahyoung LeeKi-Chul Hwang
作者单位: 1Yonsei University
2Catholic Kwandong University
3Chonbuk National University
刊名: Biological Research, 2017, Vol.50 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s40659-016-0106-3
关键词: Syk kinase inhibitorBAY61-3606VSMCProliferationMigration
英文摘要: Pathologic vascular smooth muscle cell (VSMC) proliferation and migration after vascular injury promotes the development of occlusive vascular disease. Therefore, an effective chemical agent to suppress aberrant proliferation and migration of VSMCs can be a potential therapeutic modality for occlusive vascular disease such as atherosclerosis and restenosis. To find an anti-proliferative chemical agent for VSMCs, we screened an in-house small molecule library, and the selected small molecule was further validated for its anti-proliferative effect on VSMCs using multiple approaches, such as cell proliferation assays, wound healing assays, transwell migration assays, and ex vivo aortic ring assay.
原始语种摘要: Pathologic vascular smooth muscle cell (VSMC) proliferation and migration after vascular injury promotes the development of occlusive vascular disease. Therefore, an effective chemical agent to suppress aberrant proliferation and migration of VSMCs can be a potential therapeutic modality for occlusive vascular disease such as atherosclerosis and restenosis. To find an anti-proliferative chemical agent for VSMCs, we screened an in-house small molecule library, and the selected small molecule was further validated for its anti-proliferative effect on VSMCs using multiple approaches, such as cell proliferation assays, wound healing assays, transwell migration assays, and ex vivo aortic ring assay.
全文获取路径: Springer Nature  (合作)
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来源刊物:
影响因子:1.129 (2012)

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关键词翻译
关键词翻译
  • vascular 维管的
  • smooth 平滑的
  • migration 迁移
  • kinase 激酶
  • muscle 肌肉
  • spleen 
  • occlusive 闭合的
  • inhibitor 抑制剂
  • tyrosine 酪氨酸
  • restenosis 再狭窄