Normal radial migration and lamination are maintained in dyslexia-susceptibility candidate gene homolog Kiaa0319 knockout mice
作者: Isabel Martinez-GarayLuiz G. GuidiZoe G. HollowayMelissa A. G. BaileyDaniel LyngholmTomasz SchneiderTimothy DonnisonSimon J. B. ButtAnthony P. MonacoZoltán MolnárAntonio Velayos-Baeza
作者单位: 1University of Oxford
2Cardiff University
3University of Strathclyde
4University of Central Lancashire
5Tufts University
刊名: Brain Structure and Function, 2017, Vol.222 (3), pp.1367-1384
来源数据库: Springer Nature Journal
DOI: 10.1007/s00429-016-1282-1
关键词: Kiaa0319DyslexiaNeuronal migrationAnatomyCerebral cortexDevelopment
英文摘要: Developmental dyslexia is a common disorder with a strong genetic component, but the underlying molecular mechanisms are still unknown. Several candidate dyslexia-susceptibility genes, including KIAA0319 , DYX1C1, and DCDC2 , have been identified in humans. RNA interference experiments targeting these genes in rat embryos have shown impairments in neuronal migration, suggesting that defects in radial cortical migration could be involved in the disease mechanism of dyslexia. Here we present the first characterisation of a Kiaa0319 knockout mouse line. Animals lacking KIAA0319 protein do not show anatomical abnormalities in any of the layered structures of the brain. Neurogenesis and radial migration of cortical projection neurons are not altered, and the intrinsic electrophysiological...
原始语种摘要: Developmental dyslexia is a common disorder with a strong genetic component, but the underlying molecular mechanisms are still unknown. Several candidate dyslexia-susceptibility genes, including KIAA0319 , DYX1C1, and DCDC2 , have been identified in humans. RNA interference experiments targeting these genes in rat embryos have shown impairments in neuronal migration, suggesting that defects in radial cortical migration could be involved in the disease mechanism of dyslexia. Here we present the first characterisation of a Kiaa0319 knockout mouse line. Animals lacking KIAA0319 protein do not show anatomical abnormalities in any of the layered structures of the brain. Neurogenesis and radial migration of cortical projection neurons are not altered, and the intrinsic electrophysiological...
全文获取路径: Springer Nature  (合作)
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影响因子:7.837 (2012)

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关键词翻译
关键词翻译
  • migration 迁移
  • dyslexia 诵读障碍
  • knockout 出模器
  • susceptibility 磁化率
  • radial 放射状的
  • candidate 选择物
  • subtle 稀薄的
  • indicative 象征
  • protein 蛋白质
  • homolog 同系物