Update on the effect of estradiol in postmenopause women with Alzheimer’s disease: a systematic review
作者: Yu-Long LanShuang ZouChangfu ZhangJun LiYinghui XuShao Li
作者单位: 1The First Affiliated Hospital of Dalian Medical University
2Dalian Medical University
刊名: Acta Neurologica Belgica, 2016, Vol.116 (3), pp.249-257
来源数据库: Springer Nature Journal
DOI: 10.1007/s13760-015-0593-y
关键词: EstradiolAlzheimer’s diseasePostmenopause womenTreatment
英文摘要: Abstract(#br)Estradiol (E2) has been used in the treatment of Alzheimer’s disease (AD) for many years but with various responses. Evidence from clinical studies, randomized clinical trials (RCTs), and observational studies further underscores the importance of E2 in postmenopause women diagnosed with AD. The purpose of this article is to review all clinical trials to date focusing on the E2 in AD patients to explore the evidence regarding use of E2 in AD treatments. To achieve this objective, clinical studies regarding E2 levels in AD patients and RCTs assessing AD treatment in postmenopause women were identified through searches of MEDLINE, The Cochrane Library, EMBASE, Web of Science, Ovid, and Google Scholar. E2 has demonstrated good therapeutic effectiveness in AD patients, however,...
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影响因子:0.466 (2012)

  • postmenopause 绝经后期
  • estradiol 雌二醇
  • effect 效应
  • systematic 有系统的
  • review 复审
  • women 妇女