S(+)-ketamine
作者: Helmut TrimmelRaimund HelbokThomas StaudingerWolfgang JakschBrigitte MessererHerbert SchöchlRudolf Likar
作者单位: 1Department of Anaesthesia, Emergency Medicine and Intensive Care and Karl Landsteiner Institute of Emergency Medicine, General Hospital Wiener Neustadt
2University Hospital for Neurology, Medical University Innsbruck
3Department of Medicine I, Medical University of Vienna
4Department for Anaesthesia, Intensive Care and Pain Medicine, Wilhelminen Hospital of the City of Vienna
5Department for Cardiothoracic Anaesthesia, Medical University of Graz
6AUVA Trauma Hospital
7Department for Anaesthesia and Intensive Care, General Hospital of Klagenfurt
刊名: Wiener klinische Wochenschrift, 2018, Vol.130 (9-10), pp.356-366
来源数据库: Springer Nature Journal
DOI: 10.1007/s00508-017-1299-3
关键词: KetamineAnalgesiaNeuroprotectionEmergency medicineCritical care
英文摘要: Summary(#br)S(+)-ketamine, the pure dextrorotatory enantiomer of ketamine has been available for clinical use in analgesia and anesthesia for more than 25 years. The main effects are mediated by non-competitive inhibition of the N-methyl-D-aspartate (NMDA) receptor but S(+)-ketamine also interacts with opioid receptors, monoamine receptors, adenosine receptors and other purinergic receptors. Effects on α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, metabotropic glutamate receptors (mGluR) and L‑type calcium chanels have also been described. S(+)-ketamine stimulates the sympathetic nerve system, making it an ideal drug for analgosedation or induction of anesthesia in instable patients. In addition, the neuroprotective properties, bronchodilatory, antihyperalgesic or...
全文获取路径: Springer Nature  (合作)
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影响因子:0.813 (2012)

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