Re-evaluation of soluble APP-α and APP-β in cerebrospinal fluid as potential biomarkers for early diagnosis of dementia disorders
作者: Wataru ArakiKotaro HattoriKazutomi KanemaruYuma YokoiYoshie OmachiHarumasa TakanoMasuhiro SakataSumiko YoshidaTadashi TsukamotoMiho MurataYuko SaitoHiroshi KunugiYu-ichi GotoUtako NagaokaMasahiro NagaoTakashi KomoriKunimasa ArimaKenji IshiiShigeo MurayamaHiroshi MatsudaHisateru TachimoriYumiko M. ArakiHidehiro Mizusawa
作者单位: 1National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP)
2Medical Genome Center, NCNP
3National Institute of Neuroscience, NCNP
4Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
5National Center Hospital, NCNP
6Tokyo Metropolitan Neurological Hospital
7Komoro Kogen Hospital
8Integrative Brain Imaging Center, NCNP
9National Institute of Mental Health, NCNP
10Graduate Schoo
刊名: Biomarker Research, 2017, Vol.5 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s40364-017-0108-5
关键词: Alzheimer’s diseaseBiomarkerCerebrospinal fluidMild cognitive impairmentSoluble amyloid precursor proteinTau
英文摘要: Because soluble (or secreted) amyloid precursor protein-β (sAPPβ) and -α (sAPPα) possibly reflect pathological features of Alzheimer’s disease (AD), they are potential biomarker candidates for dementia disorders, including AD and mild cognitive impairment (MCI) due to AD (MCI-AD). However, controversial results have been reported regarding their alterations in the cerebrospinal fluid (CSF) of AD and MCI-AD patients. In this study, we re-assessed the utility of sAPPα and sAPPβ in CSF as diagnostic biomarkers of dementia disorders.
原始语种摘要: Because soluble (or secreted) amyloid precursor protein-β (sAPPβ) and -α (sAPPα) possibly reflect pathological features of Alzheimer’s disease (AD), they are potential biomarker candidates for dementia disorders, including AD and mild cognitive impairment (MCI) due to AD (MCI-AD). However, controversial results have been reported regarding their alterations in the cerebrospinal fluid (CSF) of AD and MCI-AD patients. In this study, we re-assessed the utility of sAPPα and sAPPβ in CSF as diagnostic biomarkers of dementia disorders.
全文获取路径: Springer Nature  (合作)
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关键词翻译
关键词翻译
  • dementia 痴呆
  • potential 
  • cerebrospinal 脑脊髓的
  • impairment 减损
  • fluid 
  • amyloid 淀粉状朊
  • protein 蛋白质
  • soluble 可溶的
  • pathological 病理学的
  • precursor 前驱物质