Treatment of severe hospital-acquired and ventilator-associated pneumonia: a systematic review of inclusion and judgment criteria used in randomized controlled trials
作者: Emmanuel WeissWafa EssaiedChristophe AdrieJean-Ralph ZaharJean-François Timsit
作者单位: 1HUPNVS, Hôpital Beaujon, APHP
2Paris Diderot University
3Inserm UMR_S 1149 Center for Research On Inflammation Inserm/University Paris Diderot, Sorbonne Paris Cité
4UMR 1137 - IAME Team 5 – DeSCID: Decision SCiences in Infectious Diseases, control and care Inserm/University Paris Diderot, Sorbonne Paris Cité
5APHP, Hôpital Cochin
6Microbiology and infection control unit, APHP, Hôpital Avicenne
刊名: Critical Care, 2017, Vol.21 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s13054-017-1755-5
关键词: Systematic reviewHospital-acquired pneumonia treatmentVentilator-acquired pneumonia treatmentRandomized controlled trialsEndpointsInclusion criteria
英文摘要: Hospital-acquired and ventilator-associated pneumonia (HAP/VAP) are often selected for randomized clinical trials (RCTs) aiming at new drug approval. Guidelines for the design of such RCTs have been repeatedly updated by regulatory agencies. We hypothesized that large variability in the enrolled populations, the endpoints assessed and the HAP/VAP definition criteria may impact the results of these studies, and addressed this through a systematic review of HAP/VAP RCTs.
原始语种摘要: Hospital-acquired and ventilator-associated pneumonia (HAP/VAP) are often selected for randomized clinical trials (RCTs) aiming at new drug approval. Guidelines for the design of such RCTs have been repeatedly updated by regulatory agencies. We hypothesized that large variability in the enrolled populations, the endpoints assessed and the HAP/VAP definition criteria may impact the results of these studies, and addressed this through a systematic review of HAP/VAP RCTs.
全文获取路径: Springer Nature  (合作)
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影响因子:4.718 (2012)

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关键词翻译
关键词翻译
  • pneumonia 肺炎
  • ventilator 通风机
  • acquired 获得的
  • controlled 受控
  • criteria 准则
  • associated 相关的
  • review 复审
  • systematic 有系统的
  • hospital 医院
  • inclusion 包体