Effect and Safety of TNF Inhibitors in Immunoglobulin-Resistant Kawasaki Disease: a Meta-analysis
作者: Li-Jun XueRong WuGui-Lian DuYan XuKang-Yan YuanZhi-Chun FengYu-Lin PanGuang-Yu Hu
作者单位: 1SongGang Hospital
2Yanzhou University Medical School
3BAYI Children’s Hospital
刊名: Clinical Reviews in Allergy & Immunology, 2017, Vol.52 (3), pp.389-400
来源数据库: Springer Nature Journal
DOI: 10.1007/s12016-016-8581-4
关键词: Kawasaki diseaseTumor necrosis factor inhibitorCoronary artery aneurysmPrognosisMeta-analysis
英文摘要: Previous studies showed that tumor necrosis factor (TNF) inhibitors might decrease the rate of coronary artery abnormalities in pediatrics with intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD). Therefore, we aimed to evaluate the effect and safety of TNF inhibitors in IVIG-resistant KD. We undertook a meta-analysis of clinical trials identified in systematic searches of PubMed, EMBASE, Cochrane Database, and Google scholar through May 2016. Five studies were included. Overall, rate of coronary artery aneurysm was comparable between groups (relative risk (RR), 1.05; 95 % confidence interval (95 % CI), 0.60 to 1.81; P = 0.87). No significant differences were recorded between groups in coronary artery Z scores (standardized mean difference (SMD), 0.27; 95 % CI, −0.30 to...
原始语种摘要: Previous studies showed that tumor necrosis factor (TNF) inhibitors might decrease the rate of coronary artery abnormalities in pediatrics with intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD). Therefore, we aimed to evaluate the effect and safety of TNF inhibitors in IVIG-resistant KD. We undertook a meta-analysis of clinical trials identified in systematic searches of PubMed, EMBASE, Cochrane Database, and Google scholar through May 2016. Five studies were included. Overall, rate of coronary artery aneurysm was comparable between groups (relative risk (RR), 1.05; 95 % confidence interval (95 % CI), 0.60 to 1.81; P = 0.87). No significant differences were recorded between groups in coronary artery Z scores (standardized mean difference (SMD), 0.27; 95 % CI, −0.30 to...
全文获取路径: Springer Nature  (合作)
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影响因子:5.59 (2012)

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关键词翻译
关键词翻译
  • analysis 分析
  • resistant 耐久的
  • coronary 冠状的
  • artery 动脉
  • immunoglobulin 免疫球蛋白
  • significant 有效的
  • serious 认真的
  • factor 因素
  • inhibitor 抑制剂
  • confidence 信用