Neuroprotective Effect of Chitosan Oligosaccharide on Hypoxic-Ischemic Brain Damage in Neonatal Rats
作者: Wei WuWei WeiMin LuXiaoyun ZhuNing LiuYang NiuTao SunYuxiang LiJianqiang Yu
作者单位: 1Ningxia Medical University
刊名: Neurochemical Research, 2017, Vol.42 (11), pp.3186-3198
来源数据库: Springer Nature Journal
DOI: 10.1007/s11064-017-2356-z
关键词: Chitosan oligosaccharideNeonatalHypoxic-ischemicNeuroprotectionInflammatoryOxidative stress
原始语种摘要: Neonatal hypoxic-ischemic brain damage (HIBD) is one of the leading causes of neonatal mortality and permanent neurological disability worldwide and the effective treatment strategies are not yet available. It has been demonstrated that Chitosan oligosaccharide (COS) exerts protective effect in vitro ischemic brain injury. However, no information is available on possible effects of COS on neonatal HIBD. To investigate the hypothesis of the potential neuroprotective effect of COS on the brain injury due to HIBD, 7-day-old Sprague–Dawley rats were treated with left carotid artery ligation followed by exposure to 8% oxygen (balanced with nitrogen) for 2.5 h at 37 °C. After COS treatment, the cerebral damage was measured by behavior tasks, 2,3,5-triphenyltetrazolium chloride(TTC),...
全文获取路径: Springer Nature  (合作)
影响因子:2.125 (2012)

  • available 可供应的
  • COS Card Operating System
  • demonstrated 探明的储量
  • neonatal 新生儿的
  • hypoxic 含氧量低的
  • examine 
  • staining 染色
  • increased 增加
  • ischemic 福尔克曼氏麻痹
  • investigate