Novel hybrid block copolymer nanocarrier systems to load lipophilic drugs prepared by microphase inversion method
作者: Andrea GranadaIssei OtsukaThiago CaonMarcos Antonio Segatto SilvaValdir SoldiRedouane Borsali
作者单位: 1Université Grenoble Alpes, CNRS, CERMAV
2Universidade Federal de Santa Catarina
刊名: Journal of Polymer Research, 2017, Vol.24 (12)
来源数据库: Springer Nature Journal
DOI: 10.1007/s10965-017-1351-z
关键词: NanoparticleBlock copolymerOligosaccharidePolycaprolactoneSelf-assemblyDrug delivery system
原始语种摘要: Nanoparticles based on block copolymers of oligosaccharides [β-cyclodextrin (βCyD) and maltoheptaose (Mal7)] and poly( ε -caprolactone) (PCL) were prepared by microphase inversion method. Zeta-potential, particle size measurements and morphological analysis of drug-free and drug-loaded nanoparticles were performed by using, respectively, laser-doppler anemometry, dynamic and static light scattering and transmission electron microscopy. ρ-Ratio values were correlated with transmission electron microscopy observations. Both types of amphiphilic block copolymers, βCyD- b -PCL5k and Mal7- b -PCL5k, self-assembled in water to form spherical vesicles, presented a hydrodynamic diameter of 72 and 34 nm, respectively. The incorporation of drugs into...
全文获取路径: Springer Nature  (合作)
影响因子:2.019 (2012)

  • copolymer 共聚物
  • systems 系统科学与软件
  • prepared 有准备的
  • block 滑车
  • drugs 药品
  • amphiphilic 两亲的
  • inversion 倒转
  • lipophilic 亲油性
  • caprolactone 已内酯
  • microscopy 显微镜检查