Avermectin biosynthesis: stable functional expression of branched chain α-keto acid dehydrogenase complex from Streptomyces avermitilis in Escherichia coli by selectively regulating individual subunit gene expression
作者: Qianqian CuiFengli ZhouWeifeng LiuYong Tao
作者单位: 1Chinese Academy of Sciences
2University of Chinese Academy of Sciences
刊名: Biotechnology Letters, 2017, Vol.39 (10), pp.1567-1574
来源数据库: Springer Nature Journal
DOI: 10.1007/s10529-017-2389-z
关键词: AvermectinBranched chain α-keto acid dehydrogenase (BKDH) complexEscherichia coliFunctional expressionMetabolic engineeringPolyketide precursor
英文摘要: To improve the production of short branched-chain acyl-CoAs for avermectin biosynthesis, the functional expression of the branched chain α-keto acid dehydrogenase complex (BKDH) from Streptomyces avermitilis was systematically optimized by selectively regulating individual subunit expression in Escherichia coli.
原始语种摘要: To improve the production of short branched-chain acyl-CoAs for avermectin biosynthesis, the functional expression of the branched chain α-keto acid dehydrogenase complex (BKDH) from Streptomyces avermitilis was systematically optimized by selectively regulating individual subunit expression in Escherichia coli.
全文获取路径: Springer Nature  (合作)
分享到:
来源刊物:
影响因子:1.853 (2012)

×
关键词翻译
关键词翻译
  • expression 表示
  • functional 功能的
  • Escherichia 埃希氏菌属
  • biosynthesis 生物合成
  • chain 
  • dehydrogenase 脱氢酶
  • complex 超群
  • branched 分枝的
  • regulating 蝶的
  • subunit 亚单位