The oxidative DNA damage response: A review of research undertaken with Tsinghua and Xiangya students at the University of Pittsburgh
作者: Arthur S. LevineLuxi SunRong TanYing GaoLu YangHao ChenYaqun TengLi Lan
作者单位: 1UPMC Hillman Cancer Center
2University of Pittsburgh School of Medicine
3Central South University
4Tsinghua University
刊名: Science China Life Sciences, 2017, Vol.60 (10), pp.1077-1080
来源数据库: Springer Nature Journal
DOI: 10.1007/s11427-017-9184-6
关键词: DNA damageChromatinTelomereDNA repair
英文摘要: Endogenous stress and exogenous toxicants (chemicals and UV light) alter genetic information either directly or indirectly through the production of reactive oxygen species (ROS), thereby driving genomic instability in cells and promoting tumorigenesis. All living cells try to faithfully preserve and transmit their genomic information from one generation to the next using DNA repair mechanisms to repair oxidative DNA damage to prevent cancer or premature aging. Oxidative DNA damage comprises a mixture of DNA lesions including base damage, DNA single strand breaks (SSBs), and DNA double strand breaks (DSBs). This review summarizes some of the studies on DNA damage response at a defined genome locus that are performed by students from the Tsinghua University School of Medicine and the...
原始语种摘要: Endogenous stress and exogenous toxicants (chemicals and UV light) alter genetic information either directly or indirectly through the production of reactive oxygen species (ROS), thereby driving genomic instability in cells and promoting tumorigenesis. All living cells try to faithfully preserve and transmit their genomic information from one generation to the next using DNA repair mechanisms to repair oxidative DNA damage to prevent cancer or premature aging. Oxidative DNA damage comprises a mixture of DNA lesions including base damage, DNA single strand breaks (SSBs), and DNA double strand breaks (DSBs). This review summarizes some of the studies on DNA damage response at a defined genome locus that are performed by students from the Tsinghua University School of Medicine and the...
全文获取路径: Springer Nature  (合作)
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影响因子:2.024 (2011)

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关键词翻译
关键词翻译
  • DNA Deoxyribonucleic Acid
  • damage 损伤
  • genomic 染色体组的
  • indirectly 间接地
  • oxidative 氧化的
  • strand 海滨
  • genetic 遗传的
  • breaks 劣地形
  • either 任何
  • repair 修理