Bio-cellular processes modeling on silicon substrate: receptor–ligand binding and Michaelis Menten reaction

作者： | Maria Waqas, Muhammad Khurram, S. M. Rezaul Hasan |

作者单位： |
^{1}NED University of Engineering and Technology^{2}Massey University |

刊名： | Analog Integrated Circuits and Signal Processing, 2017, Vol.93 (2), pp.329-340 |

来源数据库： | Springer Nature Journal |

DOI： | 10.1007/s10470-017-1044-x |

关键词： | Analog electronic circuit modeling; Bio-cellular systems; Enzymatic reactions; Receptor–ligand binding; Michaelis Menten kinetics; Velocity saturated short channel MOS transistor; |

英文摘要： | There has been a growing interest and motivation in analog electronic circuit modeling of bio-cellular networks, which forms the basis of cellular functions of all living organisms. The complexity and size of such networks has made this task arduous, while opening up new opportunities as well. A number of modeling techniques, from mathematical models to computer simulations, have been used in this domain to aid the interpretation of such complex and sophisticated networks. This research article focuses on modeling of bio-cellular structures and processes on silicon substrate using transistors in analog domain. MOS transistor analogies for some very commonly found bio-cellular reactions namely receptor–ligand kinetics and Michaelis Menten kinetics have been presented, which are based on... |

原始语种摘要： | There has been a growing interest and motivation in analog electronic circuit modeling of bio-cellular networks, which forms the basis of cellular functions of all living organisms. The complexity and size of such networks has made this task arduous, while opening up new opportunities as well. A number of modeling techniques, from mathematical models to computer simulations, have been used in this domain to aid the interpretation of such complex and sophisticated networks. This research article focuses on modeling of bio-cellular structures and processes on silicon substrate using transistors in analog domain. MOS transistor analogies for some very commonly found bio-cellular reactions namely receptor–ligand kinetics and Michaelis Menten kinetics have been presented, which are based on... |

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