Vaccination Against Hydatidosis: Molecular Cloning and Optimal Expression of the EG95NC − Recombinant Antigen in Escherichia coli
作者: M. JazouliM. LightowlersC. G. GauciK. TadlaouiA. BelmlihM. M. EnnajiM. Elharrak
作者单位: 1Multi-Chemical Industry
2The University of Melbourne
3University Hassan II-Casablanca
刊名: The Protein Journal, 2017, Vol.36 (6), pp.472-477
来源数据库: Springer Nature Journal
DOI: 10.1007/s10930-017-9742-x
关键词: Echinococcus granulosusHydatidosisEscherichia coliRecombinant proteinVaccine
原始语种摘要: Cystic echinococcosis (CE) is a widely distributed zoonosis that is highly endemic in the Mediterranean basin. The disease represents a serious public health threat and causes economic losses. The parasite life-cycle involves dogs and ruminants as definitive and intermediate hosts; humans are accidently infected, causing serious clinical issues. Vaccination of ruminants and dog treatments represent the most efficient measures to prevent parasite transmission. The recombinant protein vaccine, EG95, has been used successfully in sheep vaccine trials against CE in several countries. In this study, we expressed the modified antigen, EG95NC-GST, in Escherichia coli for use as a vaccine against Echinococcus granulosus in ruminants. We tested three different media formulations for E. coli...
全文获取路径: Springer Nature  (合作)
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影响因子:1.126 (2012)

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关键词翻译
关键词翻译
  • Escherichia 埃希氏菌属
  • parasite 寄生物
  • echinococcosis 包虫病
  • zoonosis 人畜共患传染病
  • protein 蛋白质
  • vaccine 菌苗
  • affinity 亲和力
  • recombinant 重组体
  • against 反对
  • serious 认真的