Somatic PI3K activity regulates transition to the spermatocyte stages in Drosophila testis
作者: Samir GuptaKrishanu Ray
作者单位: 1Tata Institute of Fundamental Research
刊名: Journal of Biosciences, 2017, Vol.42 (2), pp.285-297
来源数据库: Springer Nature Journal
DOI: 10.1007/s12038-017-9678-5
关键词: DrosophilaPhosphatidylinositol-3-kinase (PI3K)Somatic cyst cellSpermatocyteSpermatocyte-arrestTestisTraffic-jam
英文摘要: Spermatogenesis, involving multiple transit amplification divisions and meiosis, occurs within an enclosure formed by two somatic cells. As the cohort of germline cells divide and grow, the surface areas of the somatic cells expand maintaining a tight encapsulation throughout the developmental period. Correlation between the somatic cell growth and germline development is unclear. Here, we report standardization of a quantitative assay developed for estimating the somatic roles of target molecules on germline division and differentiation in Drosophila testis. Using the assay, we studied the somatic roles of phosphatidylinositol-3-kinase (PI3K). It revealed that the expression of PI3KDN is likely to facilitate the early germline development at all stages, and an increase in the...
原始语种摘要: Spermatogenesis, involving multiple transit amplification divisions and meiosis, occurs within an enclosure formed by two somatic cells. As the cohort of germline cells divide and grow, the surface areas of the somatic cells expand maintaining a tight encapsulation throughout the developmental period. Correlation between the somatic cell growth and germline development is unclear. Here, we report standardization of a quantitative assay developed for estimating the somatic roles of target molecules on germline division and differentiation in Drosophila testis. Using the assay, we studied the somatic roles of phosphatidylinositol-3-kinase (PI3K). It revealed that the expression of PI3KDN is likely to facilitate the early germline development at all stages, and an increase in the...
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来源刊物:
影响因子:1.759 (2012)

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关键词翻译
关键词翻译
  • somatic 躯体的
  • spermatocyte 精母细胞
  • transition 转移
  • testis 睾丸
  • development 开发
  • activity 活度
  • likely 大概
  • facilitate 简化
  • expression 表示
  • early