Association of ABCB1 promoter methylation with aspirin exposure, platelet function, and clinical outcomes in Chinese intracranial artery stenosis patients
作者: Xingang LiKun ZhaoNing MaShusen SunZhongrong MiaoZhigang Zhao
作者单位: 1Capital Medical University
2Capital Medical University, National Clinical Research Center for Neurological Diseases
3Western New England University
刊名: European Journal of Clinical Pharmacology, 2017, Vol.73 (10), pp.1261-1269
来源数据库: Springer Nature Journal
DOI: 10.1007/s00228-017-2298-z
关键词: ABCB1MethylationAspirinSalicylic acidThromboelastographyIschemic events
英文摘要: DNA methylation typically acts to repress gene transcription. ABCB1 is involved in the intestinal absorption of aspirin. We aimed to investigate the impact of methylation status of ABCB1 promoter on aspirin exposure, platelet function, and clinical outcomes in Chinese intracranial artery stenosis patients receiving antiplatelet treatment.
原始语种摘要: DNA methylation typically acts to repress gene transcription. ABCB1 is involved in the intestinal absorption of aspirin. We aimed to investigate the impact of methylation status of ABCB1 promoter on aspirin exposure, platelet function, and clinical outcomes in Chinese intracranial artery stenosis patients receiving antiplatelet treatment.
全文获取路径: Springer Nature  (合作)
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影响因子:2.741 (2012)

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关键词翻译
关键词翻译
  • aspirin 阿司匹林
  • intracranial 颅内的
  • stenosis 压缩
  • antiplatelet 抗血小板的
  • methylation 甲基化酌
  • Association 美国公共卫生协会
  • artery 动脉
  • promoter 催化剂
  • events 定时
  • function 函数