The Role of Oxidative Stress in Amyotrophic Lateral Sclerosis and Parkinson’s Disease
作者: Athan BailletVanessa ChanteperdrixCandice TrocméPierre CasezCatherine GarrelGérard Besson
作者单位: 1Neurology Department, Hôpital A. Michallon
2Biology Department, Hôpital A Michallon
3Laboratory of Enzymology/DBPC, CHU Hôpital Michallon
4Medical Information Unit, A. Michallon
5Grenoble University, Hôpital A. Michallon
刊名: Neurochemical Research, 2010, Vol.35 (10), pp.1530-1537
来源数据库: Springer Nature Journal
DOI: 10.1007/s11064-010-0212-5
关键词: Oxidative stressReactive oxygen speciesNeurodegenerationTrace elementAmyotrophic lateral sclerosisParkinson’s diseaseGlutathione peroxidaseSuperoxide dismutase
英文摘要: Abstract(#br)We examined oxidative stress markers of 31 patients suffering from ALS, 24 patients suffering from PD and 30 healthy subjects were included. We determined the plasma levels of lipid peroxidation (malondialdehyde, MDA), of protein oxidative lesions (plasma glutathione, carbonyls and thiols) and the activity of antioxidant enzymes i.e. erythrocyte Cu,Zn-Superoxide dismutase (SOD), Glutathione peroxidase (GSH-Px) and catalase. MDA and thiols were significantly different in both neurodegenerative diseases versus control population. A trend for an enhancement of oxidized glutathione was noted in ALS patients. Univariate analysis showed that SOD activity was significantly decreased in ALS and GSH-Px activity was decreased in PD. After adjusting for demographic parameters and enzyme...
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影响因子:2.125 (2012)

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