Polycationic amphiphiles based on triethylenetetramine and their transfection efficacy
作者: P. A. PuchkovK. A. PerevoshchikovaI. A. KartashovaA. S. LunevaT. O. KabilovaN. G. MorozovaM. A. ZenkovaM. A. Maslov
作者单位: 1Moscow Technological University
2Siberian Branch, Russian Academy of Sciences
刊名: Russian Journal of Bioorganic Chemistry, 2017, Vol.43 (5), pp.561-569
来源数据库: Springer Nature Journal
DOI: 10.1134/S1068162017050107
关键词: Polycationic amphiphilesTriethylenetetramineCationic liposomesTransfectionNucleic acid delivery
英文摘要: Novel polycationic amphiphiles derived from triethylenetetramine, a spermine analogue, containing cholesterol or dialkylglycerol residues as hydrophilic domains were synthesized. The amphiphiles and a helper lipid 1,2-dioleoyl- sn -glycero-3-phosphoethanolamine) served for the preparation of cationic liposomes, physicochemical properties of which were evaluated. A comparative study of cytotoxicity and transfection efficiency demonstrated that the replacement of spermine by triethylenetetramine decreased transfection activity of cationic liposomes.
原始语种摘要: Novel polycationic amphiphiles derived from triethylenetetramine, a spermine analogue, containing cholesterol or dialkylglycerol residues as hydrophilic domains were synthesized. The amphiphiles and a helper lipid 1,2-dioleoyl- sn -glycero-3-phosphoethanolamine) served for the preparation of cationic liposomes, physicochemical properties of which were evaluated. A comparative study of cytotoxicity and transfection efficiency demonstrated that the replacement of spermine by triethylenetetramine decreased transfection activity of cationic liposomes.
全文获取路径: Springer Nature  (合作)
分享到:
来源刊物:
影响因子:0.523 (2012)

×
关键词翻译
关键词翻译
  • transfection 转染
  • cationic 阳离子的
  • demonstrated 探明的储量
  • spermine 精胺
  • cholesterol 胆甾醇
  • analogue 相似体
  • comparative 比较的
  • helper 助手
  • efficacy 效验
  • efficiency 效率