MCM-2 and MCM-5 Expression in Gastric Adenocarcinoma: Clinical Significance and Comparison with Ki-67 Proliferative Marker
作者: Constantinos GiaginisAthina GiaginiGerasimos TsourouflisElisavet GatzidouEmmanuel AgapitosGregorios KouraklisStamatios Theocharis
作者单位: 1University of Athens
刊名: Digestive Diseases and Sciences, 2011, Vol.56 (3), pp.777-785
来源数据库: Springer Nature Journal
DOI: 10.1007/s10620-010-1348-5
关键词: MCM-2MCM-5Ki-67Proliferative markersClinicopathological parametersPrognosis
英文摘要: Abstract(#br) Background(#br)Minichromosome maintenance (MCM) proteins are essential components of DNA replication, being related to cell proliferation, and serve as useful biomarkers for cancer screening, surveillance and prognosis. The aim of the present study was to evaluate the clinical significance of MCM-2 and MCM-5 expression in gastric adenocarcinoma in comparison with Ki-67 proliferative marker.(#br) Methods(#br)MCM-2, MCM-5 and Ki-67 expression was assessed immunohistochemically in 66 tumoral samples of gastric adenocarcinoma patients and was statistically analyzed in relation to clinicopathological characteristics and patient survival.(#br) Results(#br)MCM-2 expression did not show significant associations with any clinicopathological parameters, while Ki-67 expression was...
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影响因子:2.26 (2012)

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