Preparation of temozolomide-loaded polymer particles and study of their antitumor activity in models of glioma and melanoma
作者: E. D. NikolskayaO. A. ZhuninaE. A. VasilenkoN. G. YabbarovO. G. TereshchenkoM. B. SokolV. I. PopenkoE. S. Severin
作者单位: 1Russian Research Center for Molecular Diagnostics and Therapy
2Nizhny Novgorod State University
3Russian Academy of Sciences
刊名: Russian Journal of Bioorganic Chemistry, 2017, Vol.43 (5), pp.552-560
来源数据库: Springer Nature Journal
DOI: 10.1134/S1068162017050090
关键词: TemozolomideAntitumor activityPolymer nanoparticlesPLGAGliomaMelanoma
英文摘要: Temozolomide (TMZ) is a cytostatic drug used in treatment of patients with malignant gliomas and melanomas. The development of innovative formulations for delivery of TMZ into target cells in order to reduce its systemic toxicity and gain prolonged effect is a topical problem of modern biotechnology and pharmacology. The article presents experimental data on development of the TMZ polymer-based formulation. The TMZ formulation presents nanoparticles with average size of 300 nm exhibiting high in vitro cytotoxic activity against melanoma and glioma cells (cell lines C6, U377MG, B16, and Mel-10). Melanoma (B16 cell line) bearing mice (C57Bl/61) treated by TMZ polymer nanoparticles revealed inhibition of tumor growth and increase of the animal lifespan. Also, loading of TMZ into the polymer...
原始语种摘要: Temozolomide (TMZ) is a cytostatic drug used in treatment of patients with malignant gliomas and melanomas. The development of innovative formulations for delivery of TMZ into target cells in order to reduce its systemic toxicity and gain prolonged effect is a topical problem of modern biotechnology and pharmacology. The article presents experimental data on development of the TMZ polymer-based formulation. The TMZ formulation presents nanoparticles with average size of 300 nm exhibiting high in vitro cytotoxic activity against melanoma and glioma cells (cell lines C6, U377MG, B16, and Mel-10). Melanoma (B16 cell line) bearing mice (C57Bl/61) treated by TMZ polymer nanoparticles revealed inhibition of tumor growth and increase of the animal lifespan. Also, loading of TMZ into the polymer...
全文获取路径: Springer Nature  (合作)
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影响因子:0.523 (2012)

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关键词翻译
关键词翻译
  • antitumor 抗癌的
  • melanoma 黑瘤
  • glioma 神经胶质瘤
  • loaded 加负荷的
  • activity 活度
  • lifespan 使用期限
  • polymer 聚合物
  • intact 完整的
  • toxicity 毒性
  • formulation 配方