Phosphoramidite reagents and solid-phase supports based on hydroxyprolinol for the synthesis of modified oligonucleotides
作者: M. Yu. TatulchenkovI. A. ProkhorenkoM. V. KvachM. E. NavakouskiI. A. StepanovaN. V. PilchenkoS. V. GontarevO. L. SharkoV. A. KorshunV. V. Shmanai
作者单位: 1National Academy of Sciences of Belarus
2Russian Academy of Sciences
3Gauze Institute of New Antibiotics
4ALC Primetech
刊名: Russian Journal of Bioorganic Chemistry, 2017, Vol.43 (4), pp.386-396
来源数据库: Springer Nature Journal
DOI: 10.1134/S1068162017040148
关键词: Modified oligonucleotidesHydroxyprolinolPhosphoramidite reagentsOligonucleotide synthesis
英文摘要: The synthesis of phosphoramidite reagents and solid-phase supports based on hydroxyprolinol for the introduction of the residues of biotin, lipoic acid, amino groups, and terminal acetylene groups at different positions of the oligonucleotide chain has been described. The efficiency of the reagents and supports has been confirmed by the synthesis of the corresponding modified oligonucleotides.
原始语种摘要: The synthesis of phosphoramidite reagents and solid-phase supports based on hydroxyprolinol for the introduction of the residues of biotin, lipoic acid, amino groups, and terminal acetylene groups at different positions of the oligonucleotide chain has been described. The efficiency of the reagents and supports has been confirmed by the synthesis of the corresponding modified oligonucleotides.
全文获取路径: Springer Nature  (合作)
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影响因子:0.523 (2012)

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关键词翻译
关键词翻译
  • synthesis 合成
  • modified 改进
  • solid 固体
  • corresponding 对应的
  • introduction 导言
  • acetylene 乙炔
  • phase 相位
  • based 基于
  • efficiency 效率
  • different 不相同的