A novel pyruvate kinase and its application in lactic acid production under oxygen deprivation in Corynebacterium glutamicum
作者: Xin ChaiXiuling ShangYu ZhangShuwen LiuYong LiangYun ZhangTingyi Wen
作者单位: 1Chinese Academy of Sciences
2University of Chinese Academy of Sciences
刊名: BMC Biotechnology, 2016, Vol.16 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12896-016-0313-6
关键词: Corynebacterium glutamicumPyruvate kinaseOxygen deprivationLactate dehydrogenaseFructose 16-bisphosphate
英文摘要: Abstract(#br) Background(#br)Pyruvate kinase (Pyk) catalyzes the generation of pyruvate and ATP in glycolysis and functions as a key switch in the regulation of carbon flux distribution. Both the substrates and products of Pyk are involved in the tricarboxylic acid cycle, anaplerosis and energy anabolism, which places Pyk at a primary metabolic intersection. Pyks are highly conserved in most bacteria and lower eukaryotes. Corynebacterium glutamicum is an industrial workhorse for the production of various amino acids and organic acids. Although C. glutamicum was assumed to possess only one Pyk ( pyk1 , NCgl2008), NCgl2809 was annotated as a pyruvate kinase with an unknown role.(#br) Results(#br)Here, we identified that NCgl2809 was a novel pyruvate kinase ( pyk2 ) in C. glutamicum ....
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影响因子:2.165 (2012)

  • deprivation 丧失
  • lactic 乳汁的
  • kinase 激酶
  • pyruvate 内酮酸盐
  • novel 长篇小说
  • oxygen 
  • application 申请
  • production 生产
  • under 在下