Prevalence and characteristics of hereditary non-polyposis colorectal cancer (HNPCC) syndrome in immigrant Asian colorectal cancer patients
作者: Jasmine LeeYin-Yi XiaoYan Yu SunJasminka BalderacchiBradley ClarkJatin DesaniVivek KumarAngela SaverimuthuKhin Than WinYiwu HuangYiqing Xu
作者单位: 1Maimonides Medical Center
2University of Pittsburgh
3CBLPath
4Woman’s Health Labs
5Meridian Medical Group-Specialty Care
6Brigham and Women’s Hospital
7Private Practice
刊名: BMC Cancer, 2017, Vol.17 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12885-017-3799-y
关键词: HnpccAsianColorectal cancerLynch syndromeScreening
英文摘要: The prevalence of Hereditary Non-Polyposis Colorectal Cancer (HNPCC) is 2 to 5% in the Caucasian population. HNPCC is caused by genomic mutations in DNA mismatch repair genes (MMR), namely MLH1, MSH2, MSH6, PMS2, and EPCAM . A non-hereditary, acquired process of hypermethylation of the MLH1 promoter can also lead to silencing of MLH1 protein expression. Diagnosis of HNPCC in patients with colorectal and other related cancers is important in the clinical treatment and surveillance of related cancers. The prevalence and clinical characteristics of HNPCC in Asian colorectal cancer patients has been reported in small studies and unique features have been suggested.
原始语种摘要: The prevalence of Hereditary Non-Polyposis Colorectal Cancer (HNPCC) is 2 to 5% in the Caucasian population. HNPCC is caused by genomic mutations in DNA mismatch repair genes (MMR), namely MLH1, MSH2, MSH6, PMS2, and EPCAM . A non-hereditary, acquired process of hypermethylation of the MLH1 promoter can also lead to silencing of MLH1 protein expression. Diagnosis of HNPCC in patients with colorectal and other related cancers is important in the clinical treatment and surveillance of related cancers. The prevalence and clinical characteristics of HNPCC in Asian colorectal cancer patients has been reported in small studies and unique features have been suggested.
全文获取路径: Springer Nature  (合作)
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来源刊物:
影响因子:3.333 (2012)

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关键词翻译
关键词翻译
  • 表示 染色体组的
  • hereditary 遗传性
  • colorectal 结肠直肠的
  • polyposis 息肉病
  • cancer 癌症
  • syndrome 症候群
  • silencing 消声
  • mismatch 不匹配
  • promoter 催化剂
  • genomic 染色体组的
  • expression 染色体组的