Computer-assisted stereology and automated image analysis for quantification of tumor infiltrating lymphocytes in colon cancer
作者: Ann C. EriksenJohnnie B. AndersenMartin KristenssonRené dePont ChristensenTorben F. HansenSanne Kjær-FrifeldtFlemming B. Sørensen
作者单位: 1Vejle Hospital
2University of Southern Denmark
3Aarhus University
4Visiopharm A/S
刊名: Diagnostic Pathology, 2017, Vol.12 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s13000-017-0653-0
关键词: Colon cancerHeterogeneityImage analysisStereologyTumor infiltrating lymphocytes
英文摘要: Precise prognostic and predictive variables allowing improved post-operative treatment stratification are missing in patients treated for stage II colon cancer (CC). Investigation of tumor infiltrating lymphocytes (TILs) may be rewarding, but the lack of a standardized analytic technique is a major concern. Manual stereological counting is considered the gold standard, but digital pathology with image analysis is preferred due to time efficiency. The purpose of this study was to compare manual stereological estimates of TILs with automatic counts obtained by image analysis, and at the same time investigate the heterogeneity of TILs.
原始语种摘要: Precise prognostic and predictive variables allowing improved post-operative treatment stratification are missing in patients treated for stage II colon cancer (CC). Investigation of tumor infiltrating lymphocytes (TILs) may be rewarding, but the lack of a standardized analytic technique is a major concern. Manual stereological counting is considered the gold standard, but digital pathology with image analysis is preferred due to time efficiency. The purpose of this study was to compare manual stereological estimates of TILs with automatic counts obtained by image analysis, and at the same time investigate the heterogeneity of TILs.
全文获取路径: Springer Nature  (合作)
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来源刊物:
影响因子:1.85 (2012)

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关键词翻译
关键词翻译
  • stereology 体视学
  • image 
  • infiltrating 浸润的
  • analysis 分析
  • automated 自动
  • automatic 自动的
  • digital 数字的
  • technique 技术
  • stratification 层理
  • counts 计数