Enhanced Antifungal Activity by Ab-Modified Amphotericin B-Loaded Nanoparticles Using a pH-Responsive Block Copolymer
作者: Xiaolong TangJingjing DaiJun XieYongqiang ZhuMing ZhuZhi WangChunmei XieAixia YaoTingting LiuXiaoyu WangLi ChenQinglin JiangShulei WangYong LiangCongjing Xu
作者单位: 1Stem Cell Engineering Research Center, Anhui University of Science and Technology
2Department of Respiration, Tumour Hospital of Affiliated Huainan Oriental Hospital Group, Anhui University of Science and Technology
3School of Biotechnology, Southern Medical University
4Yantai City Center for Disease Control and Prevention
5Clinical Laboratory, Department of Nephrology, Huai’an Hospital Affiliated of Xuzhou Medical College
刊名: Nanoscale Research Letters, 2015, Vol.10 (1), pp.1-11
来源数据库: Springer Nature Journal
DOI: 10.1186/s11671-015-0969-1
关键词: Amphotericin BTargetabilityC. albicansNanocarrier
英文摘要: Abstract(#br)Fungal infections are an important cause of morbidity and mortality in immunocompromised patients. Amphotericin B (AMB), with broad-spectrum antifungal activity, has long been recognized as a powerful fungicidal drug, but its clinical toxicities mainly nephrotoxicity and poor solubility limit its wide application in clinical practice. The fungal metabolism along with the host immune response usually generates acidity at sites of infection, resulting in loss of AMB activity in a pH-dependent manner. Herein, we developed pH-responsive AMB-loaded and surface charge-switching poly( d , l -lactic- co -glycolic acid)- b -poly( l -histidine)- b -poly(ethylene glycol) (PLGA-PLH-PEG) nanoparticles for resolving the localized acidity problem and enhance the antifungal efficacy of AMB....
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影响因子:2.524 (2012)

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