TP53 mutation-mediated genomic instability induces the evolution of chemoresistance and recurrence in epithelial ovarian cancer
作者: Meiying ZhangGuanglei ZhuangXiangjun SunYanying ShenWenjing WangQing LiWen Di
作者单位: 1Shanghai Jiao Tong University
刊名: Diagnostic Pathology, 2017, Vol.12 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s13000-017-0605-8
关键词: Epithelial ovarian cancerTP53 mutationGenomic instabilityMDR1 copy numberRecurrence
英文摘要: Genomic instability caused by mutation of the checkpoint molecule TP53 may endow cancer cells with the ability to undergo genomic evolution to survive stress and treatment. We attempted to gain insight into the potential contribution of ovarian cancer genomic instability resulted from TP53 mutation to the aberrant expression of multidrug resistance gene MDR1 .
原始语种摘要: Genomic instability caused by mutation of the checkpoint molecule TP53 may endow cancer cells with the ability to undergo genomic evolution to survive stress and treatment. We attempted to gain insight into the potential contribution of ovarian cancer genomic instability resulted from TP53 mutation to the aberrant expression of multidrug resistance gene MDR1 .
全文获取路径: Springer Nature  (合作)
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影响因子:1.85 (2012)

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关键词翻译
关键词翻译
  • genomic 染色体组的
  • evolution 进化
  • mutation 变种
  • ovarian 卵巢的
  • instability 不稳定性
  • expression 表示
  • cancer 癌症
  • checkpoint 检查地点
  • aberrant 异常的
  • potential