Neutrophil-lymphocyte ratio as a predictive biomarker for response to high dose interleukin-2 in patients with renal cell carcinoma
作者: James A. KuzmanDavid D. StenehjemJoseph MerrimanArchana M. AgarwalShiven B. PatelAndrew W. HahnAnitha AlexDan AlbertsonDavid M. GillNeeraj Agarwal
作者单位: 1University of Utah Huntsman Cancer Institute
2University of Utah
刊名: BMC Urology, 2017, Vol.17 (1)
来源数据库: Springer Nature Journal
DOI: 10.1186/s12894-016-0192-0
关键词: Renal cell carcinomaNeutrophil lymphocyte ratioHigh dose interleukin-2
英文摘要: Immunotherapy with high-dose interleukin-2 (HD-IL2) results in long-term survival in some metastatic renal cell carcinoma (mRCC) patients but has significant acute toxicities. Biomarkers predicting response to therapy are needed to better select patients most likely to benefit. NLR (absolute neutrophil count (ANC)/absolute lymphocyte count (ALC)) is a prognostic and predicative biomarker in various malignancies. The goal was to determine whether NLR can predict response to HD-IL2 in this setting.
原始语种摘要: Immunotherapy with high-dose interleukin-2 (HD-IL2) results in long-term survival in some metastatic renal cell carcinoma (mRCC) patients but has significant acute toxicities. Biomarkers predicting response to therapy are needed to better select patients most likely to benefit. NLR (absolute neutrophil count (ANC)/absolute lymphocyte count (ALC)) is a prognostic and predicative biomarker in various malignancies. The goal was to determine whether NLR can predict response to HD-IL2 in this setting.
全文获取路径: Springer Nature  (合作)
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影响因子:1.694 (2012)

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关键词翻译
关键词翻译
  • lymphocyte 淋巴细胞
  • interleukin 白细胞间介素
  • carcinoma 癌症
  • renal 肾的
  • predictive 预言
  • response 响应
  • ratio 
  • biomarker 生物标志化合物
  • predicative 谓语的
  • absolute 绝对的