Clinical Significance of Hu-Antigen Receptor (HuR) and Cyclooxygenase-2 (COX-2) Expression in Human Malignant and Benign Thyroid Lesions
作者: Constantinos GiaginisParaskevi AlexandrouIoanna DelladetsimaIoannis KaravokyrosEugene DanasAthina GiaginiEfstratios PatsourisStamatios Theocharis
作者单位: 1University of Athens
2University of the Aegean
刊名: Pathology & Oncology Research, 2016, Vol.22 (1), pp.189-196
来源数据库: Springer Nature Journal
DOI: 10.1007/s12253-015-9997-5
关键词: Thyroid malignancyHu-antigen RCyclooxygenase-2Clinicopathological parametersImmunohistochemistry
英文摘要: Abstract(#br)Hu-antigen R (HuR) is considered to play a crucial role in tumor formation and growth by binding to mRNAs encoding proteins such as Cyclooxygenase-2 (COX-2) and inducing their expression via mRNA stabilization and/or altered translation. The present study aimed to evaluate the clinical significance of HuR and COX-2 proteins’ expression in human benign and malignant thyroid lesions. HuR and COX-2 proteins’ expression was assessed immunohistochemically on paraffin-embedded thyroid tissues obtained from 98 patients with benign ( n = 48) and malignant ( n = 50) lesions and was statistically analyzed with clinicopathological parameters, follicular cells’ proliferative capacity and recurrence risk rate. Enhanced HuR and COX-2 expression was significantly more frequently observed in...
全文获取路径: PDF下载  Springer Nature  (合作)
影响因子:1.555 (2012)