MiR-181b Antagonizes Atherosclerotic Plaque Vulnerability Through Modulating Macrophage Polarization by Directly Targeting Notch1
作者: Tian-Hui AnQuan-Wei HeYuan-Peng XiaSheng-Cai ChenSuraj BaralLing MaoHui-Juan JinYa-Nan LiMeng-Die WangJian-Guo ChenLing-Qiang ZhuBo Hu
作者单位: 1Huazhong University of Science and Technology
刊名: Molecular Neurobiology, 2017, Vol.54 (8), pp.6329-6341
来源数据库: Springer Nature Journal
DOI: 10.1007/s12035-016-0163-1
关键词: MiR-181bIschemic strokeAtherosclerotic plaque vulnerabilityMacrophage polarizationNotch1
英文摘要: Atherosclerotic plaque vulnerability is the major cause for acute stroke and could be regulated by macrophage polarization. MicroRNA-181b (miR-181b) was involved in macrophage differential. Here, we explore whether miR-181b could regulate atherosclerotic plaque vulnerability by modulating macrophage polarization and the underline mechanisms. In acute stroke patients with atherosclerotic plaque, we found that the serum level of miR-181b was decreased. Eight-week apolipoprotein E knockout (ApoE−/−) mice were randomly divided into three groups ( N = 10): mice fed with normal saline (Ctrl), mice fed with high-fat diet, and tail vein injection with miRNA agomir negative control (AG-NC)/miR-181b agomir (181b-AG, a synthetic miR-181b agonist). We found that the serum level of miR-181b...
原始语种摘要: Atherosclerotic plaque vulnerability is the major cause for acute stroke and could be regulated by macrophage polarization. MicroRNA-181b (miR-181b) was involved in macrophage differential. Here, we explore whether miR-181b could regulate atherosclerotic plaque vulnerability by modulating macrophage polarization and the underline mechanisms. In acute stroke patients with atherosclerotic plaque, we found that the serum level of miR-181b was decreased. Eight-week apolipoprotein E knockout (ApoE−/−) mice were randomly divided into three groups ( N = 10): mice fed with normal saline (Ctrl), mice fed with high-fat diet, and tail vein injection with miRNA agomir negative control (AG-NC)/miR-181b agomir (181b-AG, a synthetic miR-181b agonist). We found that the serum level of miR-181b...
全文获取路径: Springer Nature  (合作)
分享到:
来源刊物:
影响因子:5.471 (2012)

×
关键词翻译
关键词翻译
  • plaque 
  • lipoprotein 脂蛋白
  • vulnerability 脆弱性
  • macrophage 巨噬细胞
  • polarization 极化
  • stroke 笔划
  • oxidized 被氧化的
  • luciferase 荧光素酶
  • density 密度
  • targeting 导向目标